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Singh, Manish and Kundu, Somanath and Reddy M, Amarendar and Sreekanth, Vedagopuram and Motiani, Rajender K. and Sengupta, Sagar and Srivastava, Aasheesh and Bajaj, Avinash (2014) Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale, 6 (21). pp. 12849-12855. ISSN 2040-3364

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The majority of the localized drug delivery systems are based on polymeric or polypeptide scaffolds, as weak intermolecular interactions of low molecular weight hydrogelators (LMHGs, Mw <500 Da) are significantly perturbed in the presence of anticancer drugs. Here, we present l-alanine derived low molecular weight hydrogelators (LMHGs) that remain injectable even after entrapping the anticancer drug doxorubicin (DOX). These DOX containing nanoassemblies (DOX-Gel) showed promising anticancer activity in mice models. Subcutaneous injection of DOX-Gel near the tumor achieved a greater decrease in tumour load than by intravenous injection of DOX (DOX-IV), and local injection of DOX alone (DOX-Local) at the tumor site. We noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.

Item Type: Article
Subjects: Biomedical Science
Bioengineering & Devices
Biochemical and Biophysical Sciences
Depositing User: RCB Library
Date Deposited: 30 Oct 2017 05:12
Last Modified: 30 Oct 2017 05:12
URI: http://rcb.sciencecentral.in/id/eprint/100

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