[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Sharma, Yadhu and Ahmad, Altaf and Yavvari, Prabhu Srinivas and Kumar Muwal, Sandeep and Bajaj, Avinash and Khan, Farah (2019) Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice. Molecular Therapy - Nucleic Acids, 16. pp. 626-636. ISSN 21622531

[img]
Preview
Text
Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice.pdf

Download (2728Kb) | Preview

Abstract

Chronic over-nutrition promotes adipocyte hypertrophy that creates inflammatory milieu leading to macrophage infiltration and their phenotypic switching during obesity. The SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1) has been identified as an important player in inflammatory diseases involving macrophages. However, the role of SHP-1 in modulating the macrophage phenotype has not been elucidated yet. In the present work, we show that adipose tissue macrophage (ATM)-specific deletion of SHP-1 using glucan particle-loaded siRNA improves the metabolic phenotype in dietary obese insulin-resistant mice. The molecular mechanism involves AT remodeling via reducing crown-like structure formation and balancing the pro-inflammatory (M1) and anti-inflammatory macrophage (M2) population. Therefore, targeting ATM-specific SHP-1 using glucan-particle-loaded SHP-1 antagonists could be of immense therapeutic use for the treatment of obesity-associated insulin resistance.

Item Type: Article
Subjects: Biomedical Science
Bioengineering & Devices
Depositing User: RCB Library
Date Deposited: 14 Mar 2023 10:10
Last Modified: 14 Mar 2023 10:10
URI: http://rcb.sciencecentral.in/id/eprint/286

Actions (login required)

View Item View Item