Hussain, Tabish and Saha, Dhurjhoti and Purohit, Gunjan and Kar, Anirban and Kishore Mukherjee, Anand and Sharma, Shalu and Sengupta, Suman and Dhapola, Parashar and Maji, Basudeb and Vedagopuram, Sreekanth and Horikoshi, Nobuko T. and Horikoshi, Nobuo and Pandita, Raj K. and Bhattacharya, Santanu and Bajaj, Avinash and Riou, Jean-François and Pandita, Tej K. and Chowdhury, Shantanu (2017) Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex. Scientific Reports, 7 (1). ISSN 2045-2322

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Abstract

We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter of the cyclin-dependent kinase CDKNIA (p21/CIP1/WAF1). This result in TRF2 induced transcription repression of p21. Interestingly, p21 repression was through engagement of the REST-coREST-LSD1- repressor complex and altered histone marks at the p21 promoter in a TRF2-dependent fashion. Furthermore, mutational analysis shows p21 repression requires interaction of TRF2 with a p21 promoter G-quadruplex. Physiologically, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response by evading G2/M arrest in cancer cells. Together these reveal for the first time role of TRF2 in REST- repressor complex mediated transcription repression.

Item Type:	Article
Subjects:	Biomedical Science Bioengineering & Devices
Depositing User:	RCB Library
Date Deposited:	17 Jul 2020 12:12
Last Modified:	17 Jul 2020 12:12
URI:	http://rcb.sciencecentral.in/id/eprint/352

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