Kumar, Pawan and Bag, Satyabrata and Ghosh, Tarini Shankar and Dey, Prasanta and Dayal, Mayanka and Saha, Bipasa and Verma, Jyoti and Pant, Archana and Saxena, Shruti and Desigamani, Anbumani and Rana, Preety and Kumar, Dhirendra and Sharma, Naresh C. and Hanpude, Pranita and Maiti, Tushar K. and Mukhopadhyay, Asish K. and Bhadra, Rupak K. and Nair, G. Balakrish and Ramamurthy, Thandavarayan and Das, Bhabatosh (2017) Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India. Scientific Reports, 7 (1). ISSN 2045-2322

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Abstract

Emergence of antimicrobial resistant Gram-negative bacteria has created a serious global health crisis and threatens the effectiveness of most, if not all, antibiotics commonly used to prevent and treat bacterial infections. There is a dearth of detailed studies on the prevalence of antimicrobial resistance (AMR) patterns in India. Here, we have isolated and examined AMR patterns of 654 enteric pathogens and investigated complete genome sequences of isolates from six representative genera, which in aggregate encode resistance against 22 antibiotics representing nine distinct drug classes. This study revealed that ~97% isolates are resistant against ≥2 antibiotics, ~24% isolates are resistant against ≥10 antibiotics and ~3% isolates are resistant against ≥15 antibiotics. Analyses of whole genome sequences of six extensive drug resistant enteric pathogens revealed presence of multiple mobile genetic elements, which are physically linked with resistance traits. These elements are therefore appearing to be responsible for disseminating drug resistance among bacteria through horizontal gene transfer. The present study provides insights into the linkages between the resistance patterns to certain antibiotics and their usage in India. The findings would be useful to understand the genetics of resistance traits and severity of and difficulty in tackling AMR enteric pathogens.

Item Type:	Article
Subjects:	Biochemical and Biophysical Sciences
Depositing User:	RCB Library
Date Deposited:	17 Jul 2020 11:53
Last Modified:	17 Jul 2020 11:53
URI:	http://rcb.sciencecentral.in/id/eprint/363

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