Levine, Myron M and Abdullah, Salim and Arabi, Yaseen M and Darko, Delese Mimi and Durbin, Anna P and Estrada, Vicente and Jamrozik, Euzebiusz and Kremsner, Peter G and Lagos, Rosanna and Pitisuttithum, Punnee and Plotkin, Stanley A and Sauerwein, Robert and Shi, Sheng-Li and Sommerfelt, Halvor and Subbarao, Kanta and Treanor, John J and Vrati, Sudhanshu and King, Deborah and Balasingam, Shobana and Weller, Charlie and Aguilar, Anastazia Older and Cassetti, M Cristina and Krause, Philip R and Restrepo, Ana Maria Henao (2020) Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-Monitored Challenge Model of COVID-19 in Healthy Volunteers. Clinical Infectious Diseases. ISSN 1058-4838

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Abstract

WHO convened an Advisory Group (AG) to consider the feasibility, potential value and limitations of establishing a closely-monitored challenge model of experimental SARS-CoV-2 infection and COVID-19 in healthy adult volunteers. The AG included experts in design, establishment and performance of challenges. This report summarizes issues that render a COVID-19 model daunting to establish (SARS-CoV-2’s potential to cause severe/fatal illness, its high transmissibility, and lack of a “rescue treatment” to prevent progression from mild/moderate to severe clinical illness) and it proffers prudent strategies for stepwise model development, challenge virus selection, guidelines for manufacturing challenge doses, and ways to contain SARS-CoV-2 and prevent transmission to household/community contacts. A COVID-19 model could demonstrate protection against virus shedding and/or illness induced by prior SARS-CoV-2 challenge or vaccination. A limitation of the model is that vaccine efficacy in experimentally challenged healthy young adults cannot per se be extrapolated to predict efficacy in elderly/high-risk adults.

Item Type:	Article
Subjects:	Biomedical Science
Depositing User:	RCB Library
Date Deposited:	22 Sep 2020 06:29
Last Modified:	22 Sep 2020 06:29
URI:	http://rcb.sciencecentral.in/id/eprint/531

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