Gupta, Ragini and Thakur, Jyoti and Pal, Sanjay and Mishra, Deepakkumar and Rani, Parul and Kumar, Sandeep and Saini, Amandeep and Singh, Archana and Yadav, Kavita and Srivastava, Aasheesh and Prasad, Rajendra and Gupta, Siddhi and Bajaj, Avinash (2020) Cholic-Acid-Derived Amphiphiles Can Prevent and Degrade Fungal Biofilms. ACS Applied Bio Materials. ISSN 2576-6422

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Abstract

Infections caused by fungal species via their existence as biofilms on medical devices can cause organ damage via candidiasis and candidemia. Different Candida species like Candida albicans can pose a serious threat by resisting host’s immune system and by developing drug resistance against existing antimycotic agents. Therefore, targeting of fungal membranes can be used as an alternative strategy to combat the fungal infections. Here, we present screening of different amphiphiles based on cholic acid against different Candida strains as these amphiphiles can act as potent membrane-targeting antimycotic agents. Structure–activity correlations, biochemical assays and electron microscopy studies showed that amphiphiles having 4 and 6 carbon chains are most potent, safe and can act on the fungal membranes. Candida albicans did not show emergence of drug resistance on repeated usage of these amphiphiles unlike fluconazole. We show that these amphiphiles can prevent the formation of biofilms and also have the ability to degrade preformed biofilms on different substrates including acrylic teeth. We further demonstrate that amphiphiles 4 and 6 can clear the Candida albicans wound infections and prevent the biofilm formation on indwelling devices in murine models. Therefore, amphiphiles derived from cholic acid and their coatings provide suitable alternatives for inhibiting the fungal infections.

Item Type:	Article
Subjects:	Biomedical Science Bioengineering & Devices
Depositing User:	RCB Library
Date Deposited:	22 Sep 2020 06:27
Last Modified:	22 Sep 2020 06:27
URI:	http://rcb.sciencecentral.in/id/eprint/533

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