Verma, Kuldeep and Srivastava, Vijay Kumar and Datta, Sunando (2020) Rab GTPases take centre stage in understanding Entamoeba histolytica biology. Small GTPases, 11 (5). pp. 320-333. ISSN 2154-1248

Text Rab GTPases take centre stage in understanding Entamoeba histolytica biology.bib Restricted to Repository staff only Download (550b) | Request a copy

Abstract

Rab GTPases constitute the largest subgroup in the Ras superfamily of GTPases. It is well established that different Rab GTPases are localized in discrete subcellular localization and regulate the membrane trafficking in nearly all eukaryotic cells. Rab GTPase diversity is often regarded as an expression of vesicular trafficking complexity. The pathogenic amoeba Entamoeba histolytica harbours 91 Rab GTPases which is the highest among the currently available genome sequences from the eukaryotic kingdom. Here, we review the current status of amoebic Rab GTPases diversity, unique biochemical and structural features and summarise their predicted regulators. We discuss how amoebic Rab GTPases are involved in cellular processes such as endocytosis, phagocytosis, and invasion of host cellular components, which are essential for parasite survival and virulence.

Item Type:	Article
Subjects:	Biomedical Science
Depositing User:	RCB Library
Date Deposited:	29 Jul 2021 07:51
Last Modified:	29 Jul 2021 07:51
URI:	http://rcb.sciencecentral.in/id/eprint/613

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