Nair, Deepak T. and Kottur, Jithesh and Sharma, Rahul (2015) A rescue act: Translesion DNA synthesis pastN2-deoxyguanosine adducts. IUBMB Life, 67 (7). pp. 564-574. ISSN 15216543

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Abstract

Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides--termed as DNA lesions. The N(2) -atom of deoxyguanosine is particularly reactive and a number of chemicals react at this site to form different kinds of DNA adducts. The N(2) -deoxyguanosine adducts perturb different genomic processes and are particularly deleterious for DNA replication as they have a strong tendency to inhibit replicative DNA polymerases. Many organisms possess specialized dPols--generally classified in the Y-family--that serves to rescue replication stalled at N(2) -dG and other adducts. A review of minor groove N(2) -adducts and the known strategies utilized by Y-family dPols to replicate past these lesions will be presented here.

Item Type:	Article
Subjects:	Biochemical and Biophysical Sciences
Depositing User:	RCB Library
Date Deposited:	13 Nov 2017 06:18
Last Modified:	13 Nov 2017 06:18
URI:	http://rcb.sciencecentral.in/id/eprint/126

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